Remedi Therapeutix grows rare cannabinoids in living soil, concentrates them without solvents, and is preparing the preclinical studies that will show what reaches the brain.
01Tracey, Frank and Dr. Abe in their own words, from The House of Jóia, Issue 01.
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02Living soil, HALO extraction, AI ratio modeling and preclinical study.
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03The same flower before and after HALO, tested by an independent lab.
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04The Phase 0 preclinical plan and the road to clinical trials.
Open page →05Short films from the founders, the farm and the lab.
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06The founding team, and the leadership roles we are hiring for now.
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Love, landrace genetics and the next generation of cannabinoid research: the stories of the three people behind Remedi Therapeutix, told in their own words.
“It dulled everything.”TRACEY LOPA, CO-FOUNDER, ON HER YEARS OF MEDICATION
In 2006 Tracey Lopa was diagnosed with unexplained, refractory epilepsy. For fourteen years she took the medicines she was prescribed, levetiracetam (Keppra®) and lamotrigine (Lamictal®). They held back her major seizures, but the fog they brought made it hard to be present with her children.
Her husband, Frank, went looking for another way. He sourced rare CBG White genetics from an organic farm in Ohio, grew the plants in living soil and developed a cryosift technique to make custom 52 mg CBGA sift capsules. Under her doctors’ supervision, Tracey gradually tapered off lamotrigine. Within three months she was seizure-controlled, which surprised her specialists and her father, an internist.
The next chapter came when Frank found and cultivated high-CBDV hemp. In Tracey’s experience, inhaled CBDV flower or vaporized concentrate stopped her seizure auras within a minute or two, and it brought balance to her mood, anxiety and stress.
Today Tracey has been seizure-free for more than six years. She drives again, travels, and is present for every moment with her family. Her experience is why she and Frank founded Remedi: to find out, with real science, whether what happened for her can be understood, measured and made available to others.
“We don’t cultivate cannabis. We cultivate people.”FRANK LOPA, CO-FOUNDER
Frank Lopa has spent more than thirty years in cultivation, landrace genetics and solventless extraction. Through Royal Crown Farms, he and his family have self-funded decades of work preserving rare cultivars and growing them in living organic soil, in conditions that mirror each plant’s native home.
His focus on high-CBDV and rare-cannabinoid hemp is personal too. Frank is extremely sensitive to THC and lives with chronic Lyme disease and inflammation, so he needed plants that offered relief without intoxication. That led to a hemp program grown to the standard of connoisseur flower, in aroma, flavor and structure.
To keep the whole plant intact, Frank built two processes of his own:
A one-step, whole-plant short-path process with no solvents, water or ice, in development since 2013. It concentrates native terpenes and plant lipids up to 20×.
Pure trichome-head separations that yield high-potency CBG and CBDV sifts.
“CBDV doesn’t get you high, but it adds joy, like feeling the beat drop in your favorite song.”DR. ABRAHAM BENAVIDES, MD
I have evaluated top-shelf cannabis in four countries and a dozen U.S. states. When Frank called with unusual lab results and an invitation, I flew from Costa Rica to Staten Island for a two-week research visit. On arrival he handed me a single serving of CBG HALO oil. Within about three minutes I felt deeply relaxed, and that night I slept without my usual nightmares or jet lag. It felt like Charlie finding the golden ticket.
For five years I have lived with Long COVID, POTS and PTSD. Inhaling Royal Crown Farms’ whole-plant CBDV flower (es el cannabis del cielo) eased my flashbacks, intrusive thoughts, hypervigilance and racing heart, and left my mind clear for work, without the dry mouth, fog or side effects I know from THC.
When I went home, my symptoms came back. That is why I joined Remedi: what I felt in New York deserves rigorous study, and patients deserve to know whether it holds up.
The cultivars behind these stories, tested by MCR Labs. Full certificates are shared under a mutual NDA.
Short films from the people, the soil and the lab behind Remedi.
We control each step that shapes the oil, so every batch we study can be traced back to the plant it came from.
Rare-cannabinoid cultivars grown at Royal Crown Farms in living organic soil, with no pesticides or chemicals.
Vacuum short-path extraction that concentrates the whole plant with no solvents, water or ice.
Computational models help choose cannabinoid and terpene ratios aimed at specific brain targets.
Independent laboratory work to measure brain delivery and target engagement before any human study.
The same flower, tested before and after HALO by an independent laboratory.
| Compound (run) | Flower % | HALO % | Gain |
|---|
CBG- and CBDV-rich cultivars are growing today in Royal Crown Farms’ living organic soil, using Korean regenerative farming methods.
No pesticides and no chemicals. Each cultivar is tested batch by batch, and those certificates of analysis are shared with research partners.
A preclinical study plan, designed with an academic laboratory partner, to measure what our formulations do before anyone takes them.
Pharmacokinetic study in rodents, measured by LC-MS/MS, comparing how much of each compound reaches the brain against a standard carrier oil.
Laboratory assays at receptors and pathways linked to brain activity and inflammation, including TRPV1, GABA-A and IL-1β.
Standard preclinical models (PTZ or MES) that measure seizure latency, duration and threshold.
Gene-expression markers and recovery measures that show what changes, and what doesn’t, after treatment.
Rodent PK study, first formulation tested, patent filings, CNS advisory team.
Central cultivation and extraction, assay setup, HALO scale-up.
Pharma co-development and IND-enabling work on lead compounds.
Only after FDA review: Phase 1 trials and GMP-grade production.
Stories from founders, families and research partners, shared with written consent.
Reserved for a research partner or family story, added once written consent is on file.TESTIMONIAL SLOT · TEXT OR VIDEO
Each of us came to this work through a personal story. Read them in full in Formulating the Impossible.
Diagnosed with refractory epilepsy in 2006, Tracey is the reason Remedi exists and its most important voice for patients and families.
Tracey’s story →
Thirty years in landrace genetics and living-soil cultivation through Royal Crown Farms; inventor of HALO extraction and Remedi’s cryosift process.
Frank’s story →
Clinician-scientist who leads research and clinical direction, and author of “Formulating the Impossible” in The House of Jóia.
Dr. Abe’s story →Advisory or board seats are a good first step for each of these roles.
Own Phase 0 design and execution, the CNS advisory board and the path from preclinical data to IND.
Express interest →Own HALO scale-up on CBG and CBDV cultivars, a validated GMP-ready process and the formulation engine.
Express interest →Own the company’s financing strategy, with experience in biotech finance and capital markets.
Express interest →Start with a 20-minute call. We share our full briefing, certificates of analysis and process data under a mutual NDA.
Executive R&D and Clinical Director
Remedi Therapeutix · PO Box 82, Brooklyn, NY 11222
Start with a 20-minute call. Our full briefing is shared under a mutual NDA.